Computer-assisted Diagnosis of Metastases Based on Bone Scintigraphy:Lesion Detection Compared Using BONENAVI 1 and 2

Abstract

Background&Aims:This study aimed to evaluate the diagnostic performance and features of a computer-assisted diagnostic system.BONENAVI versions 1(BN1)and 2(BN2)were used to detect lesions on bone scintigraphy. Methods:Bone scintigraphy of 33 prostate cancer and 27 breast cancer patients with bone metastases was evaluated. Spots detected and analyzed by BN1 and BN2 were compared with those of manual analyses by nuclear medicine physicians. Results:The sensitivity of BN1 and BN2 was 99.2％ and 97.0％ for prostate cancer and 96.8％ and 95.0％ for breast cancer,respectively.The specificity was 64.7％ and 68.0％ for prostate cancer and 65.3％ and 75.8％ for breast cancer,respectively.Positive predictive values tended to be higher for BN2,and negative predictive values tended to be higher for BN1. BN2 showed fewer false positive spots. BN2 was superior to BN1 for detection of physiological uptake in the head and pelvis in breast cancer and in the cervical/lumbar spine in both breast and prostate cancer. Conclusions:BN2 showed better diagnostic performance than BN1.Understanding the characteristics of lesion detection using each version of BONENAVI may be useful when evaluating new lesions on bone scintigraphy.