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Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/1615

Title: Cardiovascular responses to apelin-12 injection into the ventral medullary surface in rats
Authors: Takayama, Kiyoshige
Kumaki, Iku
Motegi, Shunichi
Hou, Xing Hua
Tatemoto, Kazuhiko
Keywords: Apelin-12
Ventral medullary surface
Rostral ventrolateral medulla
Pressor response
Tachycardiac response
Issue Date: Mar-2002
Publisher: 群馬大学医学部保健学科
Citation: 群馬保健学紀要. 22, 55-58 (2002)
Abstract: We examined cardiovascular responses to the injection of apelin-12 (AP12) into the ventral medullary surface (VMS) in Wistar rats anesthetized with ethyl carbamate and pentobaribital sodium. We found that the injection of AP12 into the VMS induced pressor and tachycardiac responses. With stepwise increases in the dose (1nmol/kg. 5 nmol/kg. lOnmol/kg), the pressor and tachycardiac responses increased dose-dependently. The present results suggest that apelin peptides may play some roles in central ardiovascular regulation.
URI: http://hdl.handle.net/10087/1615
ISSN: 1343-4179
Appears in Collections:第22巻 (2002)

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