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第02巻 (1981) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/1831

Title: Macrophage chemotaxis inhibitory factor in tumor-bearing hosts
Authors: Kurashige, Satonori
Ogiwara, Keiko
Onaya, Mami
Kizumino, Atsuko
Kodaira, Takako
Kodera, Setsuko
Hasunuma, Naoko
Hara, Kayoko
Yasuoka, Junko
Yamazaki, Akiko
Watanabe, Motoko
Issue Date: 10-Mar-1982
Publisher: 群馬大学医療技術短期大学部
Citation: 群馬大学医療技術短期大学部紀要. 2, 67-80 (1982)
Abstract: Macrophage chemotaxis was inhibited by tumorgenic ascites suggesting the presence of macrophage chemotaxis inhibitory factor (MCIF). MCIF inhibited chemotaxis not only of syngeneic but also of xenogeneic macrophages through the depression of macrophage adherence. MCIF was heat-labile, and its activity was lost within 3 days at 4℃ but was preserved 2 month at -80℃. MCIF which was assayed with xenogeneic mouse macrophages was found from early stage in sera of human patients with mammary carcinoma. Ia-negative macrophages were more sensitive to MCIF than Ia-positive macrophages suggesting that nonspecific macrophage activities such as chemotactic or digestive activities were at first depressed in tumor-bearing hosts and that the depression of such activities might cause relaps of tumor cells or serious infection in tumor-bearing hosts.
URI: http://hdl.handle.net/10087/1831
ISSN: 0389-7540
Appears in Collections:第02巻 (1981)

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