Academic Knowledge Archives of Gunma Institutes >
群馬大学(Gunma University) >
35 医学部 >
3503 群馬大学医療技術短期大学部 >
350301 群馬大学医療技術短期大学部紀要 >
第09巻 (1988) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/1949

Title: Antitumor Effect of Interleukin 2 and Cyclophosphamide Administration
Other Titles: インターロイキン2及びサイクロホソファミドの抗腫瘍効果
Authors: Kurashige, Satonori
Akuzawa, Yuki
Kodama, Kazue
Keywords: Interleukin 2
Issue Date: 31-Mar-1989
Publisher: 群馬大学医療技術短期大学部
Citation: 群馬大学医療技術短期大学部紀要. 9, 169-179 (1989)
Abstract: EL4-bearing C57BL mice were treated cyclophosphamide and/or with IL2. Mice treated with cyclophosphamide alone survived significantly longer than nontreated mice, while IL2-treated mice did not. Mice treated with both cyclophosphamide and IL2 survived significantly longer than mice treated with cyclophosphamide alone. IL2 response of lymphocytes was markedly depressed in EL4-bearing mice. Lymphocytes from EL4-bearing mice treated with cyclophosphamide alone responded to IL2 significantly higher than those from mice treated with IL2 alone or those from nontreated mice. Lymphocytes from mice treated with both cyclophosphamide and IL2 responded to IL2 almost same as normal lymphocytes. Cyclophosphamide treatment protected the appearance of both suppressor factor that were found in EL4-bearing mice and inhibited IL2 response of lymphocytes. These results suggested that combination therapy of cyclophosphamide and IL2 showed synergistic antitumor effect through the protection of IL2 responsiveness from suppression by suppressors.
URI: http://hdl.handle.net/10087/1949
ISSN: 0389-7540
Appears in Collections:第09巻 (1988)

Files in This Item:

File Description SizeFormat
KJ00004436131.pdf467.37 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


DSpace Software Copyright © 2002-2010  Duraspace - Feedback