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第14巻 (1993) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/2041

Title: Antineoplastic Effects of Interferon-Alpha and -Gamma in Metastatic Renal Cell Carcinoma Xenografts in Nude Mice
Authors: Ito ,Yoshikazu Z.
Hiromachi, Sachiko
Shirahama, Akiko
Arai, Michiko
Futawatari, Tamae
Nakazato, Yoichi
Keywords: Interferon-alpha
Renal Cell Carcinoma
Nude Mice
Issue Date: 31-Mar-1994
Publisher: 群馬大学医療技術短期大学部
Citation: 群馬大学医療技術短期大学部紀要. 14, 149-157 (1994)
Abstract: Combination treatment with human natural interferon-alpha (IFN-alpha) and natural interferon-gamma (IFN-gamma) markedly reduced the weight of metastatic human renal cell carcinoma (RCC) transplanted into nude mice. Monotherapy with IFN-alpha or IFN-gamma inhibited the tumor growth without reducing the tumor weight. After combination treatment with IFN-alpha and-gamma, histological features showed notable reduction in the number of mitotic tumor cells and appreciable fibrosis in the stroma of the tumor. Infiltration of macrophages in the tumor was sparse. The results suggested that the antitumor activity of the IFNs is by direct cellular action. The general condition of tumor-bearing mice treated with IFN-alpha and-gamma was well retained, while marked emaciation was observed in the untreated tumor-bearing animals. The finding indicated that the combination treatment of RCC with IFN-alpha and-gamma may reduce the tumor burden of host mice.
URI: http://hdl.handle.net/10087/2041
ISSN: 0389-7540
Appears in Collections:第14巻 (1993)

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