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330501 The Kitakanto medical journal >
Vol.57 (2007) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/3914

Title: Sub-acute Toxicosis Caused by a Multiple Doses Tegafur/Uracil (UFT) for Suicide : A Case Report
Authors: Hagiwara, Shuichi
Ogino, Takashi
Takahashi, Yuga
Isaka, Akira
Nameki, Taro
Kagoshima, Kaie
Yamada, Takuro
Ishihara, Kouichi
Hiraishi, Hikaru
Kurabayashi, Kazutaka
Handa, Hiroshi
Iino, Yuichi
Keywords: tegafur/uracil (UFT)
suicide attempt
Issue Date: 1-Nov-2007
Publisher: 北関東医学会
Citation: The Kitakanto medical journal. 57(4), 317-320 (2007)
Abstract: Tegafur/uracil (UFT) is an oral anticancer drug composed of tegafur which is a derivative of fluorouracil (5-FU) and uracil in a molar ratio of 1:4. UFT is effective as adjuvant chemotherapy for breast cancer2, colorectal cancer3, non-small cell lung carcinoma4, head and neck cancer5 and other tumors. We report a 41-year-old man who orally ingested a large dose of UFT (tegafur: 40000 mg/ uracil 9960mg)in an effort to commit suicide, and suffered from sub-acute toxicosis(main symptoms were bone-marrow suppression, and hair loss) of UFT. His life was saved by empiric antibiotic chemical treatment (meropenem, isapamicin, and micafungin), and granulocyte colony-stimulating factor (G -CSF). In the case of toxicosis of UFT, strong antibacterial empiric chemotherapy and G-CSF are necessary for rescue. If G-CSF is not work, biopsy of bone marrow woud be necessary, and the case of no stem cells, bone marrow transfusion should be thought.
URI: http://hdl.handle.net/10087/3914
ISSN: 1343-2826
Appears in Collections:Vol.57 (2007)

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