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Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/4816

Title: Synthesis and properties of radiopaque polymer hydrogels: polyion complexes of copolymers of acrylamide derivatives having triiodophenyl and carboxyl groups and p-styrene sulfonate and polyallylamine
Authors: Okamura, M
Uehara, H
Yamanobe, T
Komoto, T
Hosoi, S
Kumazaki, T
Keywords: polymer hydrogels
polyoin complexes
transcatheter arterial embolization
Issue Date: 24-Oct-2000
Publisher: Journal of molecular structure
Citation: Journal of molecular structure. 554(1), 35-45(2000)
Abstract: In order to pursue a possibility of application of radiopaque polymer hydrogels to vascular embolization, studies were done on synthesis of iodine-containing copolyanions and properties of their hydrogels with polycation via formation of polyion complexes. Acrylamide derivatives having triiodophenyl and carboxyl groups were synthesized and copolymerized with sodium styrene sulfonate at various molar ratios of initiator to monomer and temperatures. Hydrogels were prepared by mixing aqueous solutions of the obtained radiopaque copolyanions and polyallylamine. Embolization was examined by injection of these hydrogels into vein of a removed porcine kidney as a preliminary test for transcatheter arterial embolization (TAE) for hepatocellular carcinoma. It was found that the hydrogels prepared from the copolycation obtained under particular conditions give high X-ray contrasts of the vein and remained there, though copolycations with low molecular weights had a tendency to drain through the capillaries to the peripheral tissues. It is therefore concluded that the hydrogels examined in the present study are promising for vascular embolization.
URI: http://hdl.handle.net/10087/4816
ISSN: 0022-2860
Appears in Collections:学術雑誌論文

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