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群馬大学(Gunma University) >
30 医学系研究科 >
3005 北関東医学会 >
330501 The Kitakanto medical journal >
Vol.60 (2010) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/5456

Title: F-18-FDG Positron Emission Tomography Findings Correlate Pathological Proliferative Activity of Oral Squamous Cell Carcinoma
Authors: Osamu, Toyoizumi
Noboru, Oriuchi
Mitsuyuki, Miyakubo
Tomohiro, Ishikita
Yoshiki, Nakasone
Akihide, Negishi
Keigo, Endo
Takashi, Nakajima
Kenji, Mogi
Satoshi, Yokoo
Keywords: Oral squamous cell carcinoma
FDG PET
Cellular proliferation
p53
Topoisomerase Iiα
p63
Issue Date: 1-Feb-2010
Publisher: 北関東医学会
Citation: The Kitakanto medical journal. 60(1), 1-8 (2010)
Abstract: Background : It is still controversial whether FDG uptake is correlated with cellular proliferation and prognosis of oral squamous cell carcinoma (OSC). In this study, we performed PET study and immunohistochemical analysis to elucidate the relationship between FDG uptake and expression of cellular proliferative markers and pathological prognostic markers in patients with OSC. Methods : FDG PET and immunohistochemical staining have been carried out in sixteen patients with OSC. Tumor uptake of FDG was expressed with standardized uptake value (SUV). The expression of Ki-67, Topoisomerase IIα (Topo IIα), p53, and p63 in cancer cells was quantitatively assessed with positivity of the immunohistochemical staining. SUV was compared with the results of immunohistochemical analysis. Results : FDG PET study revealed that SUV ranged from 3.6 to 22.1 with average of 10.4. Average positive rate of Ki-67, Topo IIα, p53, and p63 was 68.9%, 58.9%, 72.0%, and 65.2%, respectively. Pearson product-moment correlation coefficient analysis revealed that SUV was significantly correlated with Ki-67 (r=0.616, p=0.01), Topo IIα (r=0.677, p=0.004), p53 (r=0.613, p=0.01), and p63 (r=0.710, p=0.002), respectively. Conclusion : The present preliminary study indicated that FDG uptake was closely correlated with pathological cellular proliferative and prognostic markers in patients with OSC.
URI: http://hdl.handle.net/10087/5456
ISSN: 1343-2826
Appears in Collections:Vol.60 (2010)

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