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群馬県立県民健康科学大学(Gunma Prefectural College of Health Sciences ) >
03 紀要論文=Departmental Bulletin Paper >
群馬県立県民健康科学大学紀要 >
第07巻(2012) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/6880

Title: Whole body SPECTを用いたMIP像の有用性と事前評価
Other Titles: 従来の骨シンチグラフィとの比較
Preliminary Evaluation and Utility of MIP Imaging by Whole-Body Bone SPECT
Comparison with Conventional Bone Scintigraphy
Authors: 齋藤, 享子
高橋, 康幸
嶋田, 博孝
有坂, 有紀子
樋口, 徹也
織内, 昇
Saito, Kyoko
Takahashi, Yasuyuki
Shimada, Hirotaka
Arisaka, Yukiko
Higuchi, Tetuya
Oriuchi, Noboru
Keywords: 骨シンチグラフィ
^<99m>Tc-HMDP
SPECT
MIP法
Bone scintigraphy
^<99m>Tc-HMDP
SPECT
Maximum intensity projection
Issue Date: Mar-2012
Publisher: 群馬県立県民健康科学大学
Citation: 群馬県立県民健康科学大学紀要 7,75-82,2012
Abstract: 目的:骨シンチグラフィは,骨転移の疑われる症例について従来よりスクリーニング検査として広く用いられているが,トレーサを投与し180~240分後の検査は待ち時間が長い.本研究では全身骨SPECTによるMIP法を応用し,待ち時間の短縮を試みた.方法:基礎的検討は,模擬腫瘍としてゲルを用いた骨ファントムを独自に作成し,^<99m>Tc-HMDPの集積比(1:1.5)とHot rods サイズ(φ=4~19mm)を変化させ検出性を確認した.次に健常例では,投与後30~180分のSPECT撮像したMIP像と投与後180分のWhole body像の画質を比較した.さらに,乳がん患者17例につき集積部位の検出性を医師より視覚評価した.結果:MIP画像は4mmまで検出可能であった.健常例および臨床例では90分で^<99m>Tc-HMDPの集積が良好で,両画像の全ての所見は一致した.結論:4mmサイズは従来のSPECTのみでは検出が難しいが,MIP画像により明瞭に認識できた.散乱線補正を行ったMIP画像はBGが抑制されることから検査時間の短縮が可能となり,同時に画質も向上した.
Objectives : Bone scintigraphy is widely used as a screening tool for bone metastasis. However, the 180 to 240 min wait after intravenous (i.v.) injection of the tracer is tedious. In this study, we applied maximum intensity projection (MIP) by whole-body (WB) bone SPECT in an attempt to shorten the waiting time. Methods : In a phantom study, hot gels of ^<99m>Tc-HMDP (4, 6, 8, 10, 12, 13, 15, 16 and 19 mm in diameter, 2.5×background radioisotope count) were arrange in the bone phantom. Additionally, images from the chest to abdomen of healthy volunteers were obtained 30, 60, 90, 120 and 180 min after ^<99m>Tc-HMDP injection. MIP images were subsequently reconstructed. WB images were also obtained 180 min after ^<99m>Tc-HMDP injection, and the quality of MIP and WB images was compared. In 17 patients with breast cancer, the detectability of uptake regions (metastases) was compared visually. Results : In the phantom study, MIP images depicted a 4 mm hot gel. In healthy volunteers and clinical cases, there was sufficient accumulation of ^<99m>Tc-HMDP within 90 min. There was accordance between findings on all MIP and WB images. Conclusions : Although a 4 mm hot gel was difficult to depict on conventional SPECT, it could be clearly visualized on MIP images. MIP reconstruction with scatter correction could improve the background of the hot lesion. In addition, MIP imaging by whole-body bone SPECT produces better-quality images and shortens the testing time compared to conventional bone scintigraphy.
Description: 報告
URI: http://hdl.handle.net/10087/6880
ISSN: 1881-0691
Appears in Collections:第07巻(2012)

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