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330501 The Kitakanto medical journal >
Vol.62 (2012) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/6882

Title: Polycythemia Vera Terminating in Refractory Ascites
Authors: Toyama, Kohtaro
Mitsui, Takeki
Yokohama, Akihiko
Saitoh, Takayuki
Uchiumi, Hideki
Handa, Hiroshi
Sakuraya, Masataka
Murakami, Hirokazu
Nojima, Yoshihisa
Tsukamoto, Norifumi
Keywords: polycythemia vera
extramedullary hematopoiesis
nodular regenerative hyperplasia
JAK2-V617F mutation
Issue Date: 1-May-2012
Publisher: 北関東医学会
Citation: The Kitakanto medical journal. 2012, 62(2), p.159-162
Abstract: A 64-year-old woman,with more than a 20 year history of polycythemia vera(PV),developed portal hypertension,myelofibrosis and extramedullary hematopoiesis accompanied by massive ascites. Portal hypertension resulted not only from infiltration of the liver sinusoids by hematopoietic cells but also from nodular regenerative hyperplasia of the liver. Wright-stained smears of ascites samples consisted of mesothelial cells and macrophages. However,cultures of mononuclear cells from the ascites showed the presence of hematopoietic progenitor cells including megakaryocyte colony formation and burst forming units. The JAK2-V617F mutation was positive in granulocytes. Contrary to other reports, radiation therapy was not effective and severe myelosuppression continued for more than one month. We present the unusual clinical course for this case of PV and discuss the pathophysiology of refractory ascites.
URI: http://hdl.handle.net/10087/6882
ISSN: 1343-2826
Appears in Collections:Vol.62 (2012)

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