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Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/7014

Title: Interaction of Nicotine and N-cyanomethylmethamphetamine, a Main Pyrolysis Product of Smoking Methamphetamine Mixed with Tobacco, in Terms of the Sensitization to the Ambulatory Stimulant Effect in Mice
Other Titles: 覚せい剤混入タバコの喫煙で生じる N-cyanomethylmethamphetamineと nicotineの相互作用-マウスの移所運動促進効果に対する増感現象の修飾
Authors: KURIBARA, Hisashi
栗原、久
Keywords: N-Cyanomethylmethamphetamine
Methamphetamine
Nicotine
Ambulatory
activity
Behavioral
sensitization
Psychotoxicity
Mice
Issue Date: Nov-2010
Publisher: 東京福祉大学・大学院
Citation: 東京福祉大学・大学院紀要 1(2),121-129,2010
Abstract: N-cyanomethylmethamphetamine (CMA) is a main pyrolysis product of smoking methamphetamine (MA) mixed with tobacco, and it has MA-like central stimulant effects, acceleration of ambulation and production of various types of stereotyped behavior, and induction of sensitization to these behavioral effects following repeated administration in mice and rats. The induction of behavioral sensitization to central stimulants has been considered to be intimately related to the development of the psychotoxic symptoms following repeated abuse of these drugs. Since CMA is inhaled simultaneously with nicotine, the aim of this study was to investigate the modifications by nicotine of induction and expression of sensitization to the ambulation-increasing effect of CMA in mice. During the 5 repeated co-administrations of CMA (3 mg/kg s.c.) with nicotine (0.03, 0.1, 0.3 and 1 mg/kg s.c.) at 3 day intervals, nicotine dose-dependently inhibited the progressive enhancement of CMA-induced ambulatory stimulation. However, such treatments did not modify the induction of sensitization to the ambulatory stimulant effect of MA (2 mg/kg s.c.). The MA-sensitized mice demonstrated significant cross-sensitization to CMA. In both the drug-naive and MA-sensitized mice, nicotine reduced the ambulatory stimulant effect of CMA. These results suggest that, although nicotine acts to reduce the ambulatory stimulant effect of CMA, nicotine does not protect the induction of behavioral sensitization to CMA and MA. The repeated 5 times experience of nicotine (1mg/kg s.c.) alone did not modify the sensitivity of mice to CMA or MA. These results also indicate that nicotine does not modify the psychotoxic liability of MA following repeated smoking MA mixed with tobacco, although nicotine may reduce the reward effect of MA.
URI: http://hdl.handle.net/10087/7014
ISSN: 1883-7565
Appears in Collections:1巻2号

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