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330501 The Kitakanto medical journal >
Vol.62 (2012) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/7068

Title: Der(2)t(2;11)(p21;q23), a Variant form of t(2;11), in Biphenotypic Acute Leukemia with T Lymphoid Lineage and M yeloid Lineage Differentiation
Authors: Miyazawa, Yuri
Irisawa, Hiroyuki
Matsushima, Takafumi
Mitsui, Takeki
Uchiumi, Hideki
Saitoh, Takayuki
Handa, Hiroshi
Karasawa, Masamitsu
Murakami, Hirokazu
Tsukamoto, Norifumi
Nojima, Yoshihisa
Keywords: t(2;11)(p21;q23)
biphenotypic acute leukemia
hematopoietic stem cell
Issue Date: 1-Aug-2012
Publisher: 北関東医学会
Citation: The Kitakanto medical journal. 2012, 62(3), p.287-290
Abstract: We describe a patient with biphenotypic acute leukemia (BAL) with T-lymphoid lineage and myeloid lineage differentiation[BAL (T/M)]. Cytogenetic analysis revealed complex chromosomal abnormalities, including der(2)t(2;11)(p21;q23). Neither leukemia cells nor T-cell receptor gene rearrangements were detected in the bone marrow samples after four courses of high dose cytosine arabinoside regimen. However, der(2)t(2;11)(p21;q23) anomaly persisted in most of metaphases. Fluorescence in situ hybridization (FISH)analysis with a probe for MLL did not detect the split signal. Forty-five cases of hematological disorder with t(2;11)(p21;q23) abnormality have been previously reported. The majority of such cases have been classified as myelodysplastic syndrome(MDS) or acute myeloid leukemia (AML). This is the first case BAL (T/M) associated with a t(2;11)(p21;q23) anomaly.
URI: http://hdl.handle.net/10087/7068
ISSN: 1343-2826
Appears in Collections:Vol.62 (2012)

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