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Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/7180

Title: Alcohol Intoxication and Drunken Frenzy and/or Hangover Models in Terms of Discrete Shuttle Avoidance Behavior in Mice
Other Titles: マウスのシャトル型非連続回避反応からみた酩酊と悪酔いモデル
Authors: KURIBARA,Hisashi
栗原、久
Keywords: Ethanol
Acetaldehyde
抗酒薬
酩酊
悪酔いモデル
シャトル型非連続回避反応
マウス
Issue Date: 31-Mar-2012
Publisher: 東京福祉大学・大学院
Citation: 東京福祉大学・大学院紀要、2(2)、p97-104
Abstract: The aim of this study was to assess the modification of the behavioral effect of ethanol by antialcoholic drugs, Ca-cyanamide and disulfiram, in terms of discrete shuttle avoidance response in mice. Ethanol (2g/kg p.o.) significantly increased the response rate due to its disinhibitory action. Although the single administration of Ca-cyanamide (1-10 mg/kg p.o.) or disulfiram (3-30 mg/kg p.o.) did not change the response rate, these drugs inhibited the ethanol-induced increase in the response rate. A similar reduction of the response rate was produced by the single administration of acetaldehyde (1-10mg/kg p.o.), and the combined administration of ethanol (2 g/kg) + acetaldehyde (1-10 mg/kg). These results suggest that the combined administration of ethanol and antialcoholic drugs may cause an accumulation of acetaldehyde, and may decrease in the response rate. In summary, it is expected that the present experimental conditions of the discrete shuttle avoidance can be applied to behaviorally investigate not only the disinhibition (alcohol intoxication) but also the drunken frenzy (sickness) and/or hangover induced by ethanol in mice.
URI: http://hdl.handle.net/10087/7180
ISSN: 1883-7565
Appears in Collections:2巻2号

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