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No.16(2005) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10087/8997

Title: Ultrastructu rSatludy on Malignant Eccrine Poroma with Specia lReference to Cell Junction
Other Titles: 悪性エクリン管孔腫の細胞接着装置に関する超微形態学的研究
Authors: Senoo, Akira
瀬野尾, 章
Keywords: Ultrastructure
Malignant eccrine poronoma
Cell junction
Differential diagnosis
Issue Date: 6-Dec-2005
Citation: 桐生短期大学紀要16, 1-5
Series/Report no.: 桐生短期大学紀要;
Abstract: We reportjunctienal complex (alte rtiegdhtjunction ,desmosomes and gap junctio ni)n tumor cells of malignant eccrine porema (eccr ipnoreocarcinoma )in a 74-year-o lJdapanes ewoman. Histopathologicall y,the tumor consisted of irregular cords and lobule sef tumor cells infi]trat dienrgmis .The tumor cells varied from smaller round cells to larger bizarre-shaped gian tcells. Nuclear atypia and rnitosis were presentc dS.mall duct formation was recognized at some parts of tumor. Ultrastructur atlhle yt,umor cclls showed euchromatic nuclei with prominen tnucleoli, large amount of free polysomes, a few scattered tonofilaments ,and a few intracyteplas mciavcities. Moreover, small-sized desmosomes, tight junctio nansd gap junctio wnerse frequent loybserved. These juncti oconmapllex may represent that the tumor cells originated from the epithelial cells of eccrine duct ,und may facilita ttehe diagnosis of porocarcinom afrom invasive keretinocyti ctumors. This is the first repoTt ofjunctional complex in malignant eccrine poroma in the 1iterature.    悪性エクリン管孔腫はエクリン管上皮細胞山来の稀な腫瘍で,表皮基底細胞癌などの皮膚腫瘍との鑑別が難しいことが多い.今回, 著者は74 歳女性の悪性エクリン管孔腫について組織学的並びに超微形態的に検討した.組 織学的に腫瘍細胞は不規則な索状あるいは小葉構造を呈し真皮内に浸潤していた.個々の腫瘍細胞は小円形細胞 から大型の不定形細胞まで存在し,核異型や核分裂像も認められた.小腺腔も.部で認められた.超微形態的に は,腫瘍細胞は核小体明瞭なユークロマチンに富む核を持ち,細胞質内には豊富な遊離ポリソーム,少量のトノフィラメントや一部で小腺腔が観察された.これに加え細胞接着装胃がしばしば観察された.この細胞接着装置の存在は腫瘍細胞が腺上皮由来であることを意味するもので,皮膚腫瘍のなかでエクリン管孔腫や悪性エクリン管孔腫の診断を容易にするものと考えられた,悪性エクリン管孔腫における細胞接着装置に関する報告は調べた限りでは始めての報告である.
URI: http://hdl.handle.net/10087/8997
ISSN: 13424076
Appears in Collections:No.16(2005)

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